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The RNA-dependent RNA polymerase (NSP12) and helicase (NSP13) of the replication-transcription complex (RTC) are the most conserved proteins when considering the rate of change at each amino acid site (homologies or nucleic acid diversity) over the course of the SARS-CoV-2 pandemic or conservation in sequence across HCoVs and the coronavirus family [62]

Sulphur heteroatoms are oxidised to sulfoxides (Figure 3) and sulfones

Boban Blagaic A, Blagaic V, Mirt M, et al

The P values have been represented by comparing the data pairwise with wild type untreated controls and are mentioned in figure legends