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[PMC free article: PMC3522821] [PubMed: 22835053] (Letter discussing use of a single timed plasma concentration of acetaminophen [150 mg/L: ~1 mmol/L] to recommend acetylcysteine therapy after suspected acetaminophen overdose)

A., Govea-Salas, M., Pintado, M

Role of electrolyte concentrations and renin-angiotensin-aldosterone activation in the staging of canine heart disease

To overcome these challenges, ongoing research is focused on the development of fourth-generation EGFR inhibitors, combination therapies targeting parallel signaling pathways and novel therapeutic approaches such as antibody-drug conjugates and bispecific antibodies directed against EGFR (65,66)