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Funding This work was supported by the Henan Provincial Breast Cancer Precision Prevention and Control Engineering Research Center (ZC20220050), the Henan Provincial Peoples Hospital23456 Talent Engineering Project (ZC23456026) and the study on the Effect and Mechanism of Macrophage-Derived Exosomes Loaded with Doxorubicin for Targeted Therapy of Triple-Negative Breast Cancer (ZC20220114)

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As an intermediate product of the mevalonate pathway, IPP is required for isoprenylation of selenocysteine tRNA, which is indispensable for synthesizing selenoprotein GPX4

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