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In cardiac cells, the physical proximity between mitochondria and the sarcoplasmic reticulum (SR, a specific type of ER in heart and skeletal muscle cells) allows the exchange of Ca 2+ in local microdomains, providing rapid Ca 2+ buffering

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77,78 Supercomplex assembly is also connected to OMA1-dependent remodelling of the mitochondrial cristae

[57] This was followed in 1975 with the introduction of intravenous fat emulsions and vitamins which were added to form "total parenteral nutrition", or that which includes protein, fat, and carbohydrates

Induction of autophagy in rats upon overexpression of wild-type and mutant optineurin gene