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Preclinical investigations consistently demonstrate neuroprotective, anti-inflammatory, and monoaminergic effects, strengthening biological plausibility

5b), using the laboratory measurements of number of active sites per mass of RuBisCO combined with the ambient RuBisCO concentrations

doi: 10.1016/j.jaci.2004.04.004

Verdict at a Glance Cortistatin has the superior mechanistic profile, with a well-defined receptor pharmacology, clear sleep-promoting mechanism through cortical synchronization, and endogenous homeostatic sleep factor properties