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Metformin and vitamin B 12 deficiency Metformin-induced vitamin B 12 deficiency was reported as early as 1971 when Tomkin et al

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Also, pentadecapeptide BPC 157, given peripherally, could affect sphincter function through serotonin (51, 52) or dopamine (in the same dose-range that BPC 157 prevented/reversed catalepsy or stereotypy and all concomitant gastrointestinal lesions) (53-56), likely providing a particular balance between peripheral and central effects (57)