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The ratio of active GSH to oxidized GSSG is one of the most critical biomarkers scientists use to measure intracellular oxidative stress

The main pharmacological effects and underlying mechanism of action of rutin contribute to its antioxidant capacity through the Nrf2/ARE and anti-inflammatory properties due to NF-B, COX-2, IL-6, and TNF- suppression

doi: 10.1016/j.freeradbiomed.2014.03.027

Note that this patch approach is very different than drug patches, which contain concentrated chemicals

In addition, increased levels of ROS can trigger chronic inflammation by upregulating inflammatory pathways (Lushchak and Storey, 2021