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Senescence and the SASP: many therapeutic avenues

BACE1 is an enzyme responsible for producing beta-amyloid peptides, which are known to aggregate and form plaques in the brains of Alzheimers disease patients

Hydrogen bonds were also commonly formed with ASP135, THR141 and ARG178 in 1GP1 in this analysis indicating that interactions with these amino acids are important for inhibitor binding [22]