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In the nigrostriatal tract system, dopamine undergoes autooxidation or oxidative deamination by monoamine oxidase-B, both of which aggravates with age, leading to increased production of peroxides and hydroxyl radicals 41

2019;17:400 Zohny SM, Habib MZ, Mohamad MI, Elayat WM, Elhossiny RM, El-Salam MFA, et al

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Evidence From Preclinical & Clinical Studies A) Skin permeation & bioavailability In-vitro penetration: A Franz-cell model showed human skin penetration of GHK-Cu in vitro, supporting the feasibility of topical delivery (PMC)