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A REGISTRY-BASED CASE-CONTROL STUDY Guri Hagberg 1,2 , Hkon Ihle-Hansen 3,4 , Tamar Abzhandadze 2,5 , Malin Reinholdsson 2,5 , Adam Viktorisson 2,6 , Henri Pesonen 7 , Hege Ihle-Hansen 4 , Katharina Stibrant Sunnerhagen 2,6 1 Oslo Stroke Unit, Department of Neurology, Oslo University Hospital, Oslo, Norway, 2 Institute of Neuroscience and Physiology, Section for Clinical Neuroscience and Rehabilitation, Gothenburg University, Gothenburg, Sweden, 3 Department of Medicine, Brum Hospital- Vestre Viken Hospital Trust, Drammen, Norway, 4 Research department Brum Hospital, Vestre Viken Hospital Trust, Drammen, Norway, 5 Department of Occupational Therapy and Physiotherapy, Sahlgrenska University Hospital, Gothenborg, Sweden, 6 Neurocare, Sahlgrenska University Hospital, Gothenburg, Sweden, 7 Oslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway Background and Aims: Patient reported outcome measures (PROMs) could expose meaningful differences but are scarcely investigated in acute stroke trials

10.13004/kjnt.2025.21.e9 139 StevensG

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What it does not establish is that this process is ever visible to the naked eye as a temporary worsening in normal, healthy skin outside a wound-healing context, or that it happens in a way tied to dose or frequency of use

In the latter case, astrocyte swelling is either caused by the accumulation of glutamate alone or by ions, whose transport is activated by the binding of glutamate to mGluRs