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Acknowledgements This study was supported by the National Natural Science Foundation of China (82101326), Municipal University (Faculty) joint funding project (2024A03J1150), Key Research and Development Program of Guangzhou (2023B03J0631), Municipal University (Faculty) joint funding project (2024A03J1214) and Guangdong Basic and Applied Basic Research Foundation (2022B1515230004)

According to the study (NCT04322188), patients with rapidly developing COVID-19 respiratory pneumonia who require supplemental oxygen may benefit from siltuximab (IL-6R monoclonal antibody) therapy due to lower death and chemokines hyper-inflammation in Figure 5