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Gene Set Enrichment Analysis (GSEA) using TCGA cohort as testing cohort demonstrated that high M1 level significantly enriched gene sets related to cell proliferation, such as, MTORC1_SIGNALING, PI3K_AKT_MTOR_SIGNALING, MYC_TARGETS_v1, MYC_ TARGETS_v2 (Fig

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Discussion In summary, this study reports on the rational design, synthesis, and in-depth biological evaluation of tumor-targeting ruthenium containing nanoreactors for glutathione oxidation catalysis in osteosarcoma cells with a 1% O 2 atmosphere

This compatibility may result in more predictable dose-response relationships and reduced potential for drug-drug interactions

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