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R Met/Met individuals have higher synaptic dopamine and norepinephrine (because COMT clears them more slowly), which improves prefrontal cortex function and working memory but increases susceptibility to stress-related anxiety, pain sensitivity, and catechol estrogen accumulation

Hence, much attention was paid to the disruption of the Wnt/-catenin pathway functioning by reducing catenin activity [55]

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Disclosures: Shikha Sundaram: MIRUM: Advisor, IPSEN: Advisor, Swati Ghosh: Nothing to Disclose, Alexander Chaidez: Nothing to Disclose, Ronald Sokol: Nothing to Disclose 2478 ADVANCED HEPATIC FIBROSIS BY MR ELASTOGRAPHY IS ASSOCIATED WITH ABNORMAL SERUM LIVER BIOCHEMISTRIES IN PEDIATRIC PRIMARY SCLEROSING CHOLANGITIS (PSC) Alexander Miethke 1 Cara Mack 2 Kieran Hawthorne 3 Lisa Henn 3 Pamela Valentino 4 Kathleen Loomes 5 Mary Elizabeth Tessier 6 Adina Alazraki 7 Judy Squires 8 Rohit Kohli 9 Mark Deneau 10 Estella Alonso 11 Molly Bozic 12 Amanda Ricciuto 13 Shikha Sundaram 14 Andrew Trout 15 Jonathan Dillman 15 , 1 Cincinnati Children's Hospital Medical Center, 2 Medical College of Wisconsin, 3 Arbor Research Collaborative for Health, 4 University of Washington, 5 The Children's Hospital of Philadelphia, 6 Texas Children's Liver Center - Baylor College of Medicine, 7 Children"s Healthcare of Atlanta, 8 University of Pittsburgh Medical Center, 9 Children's Hospital Los Angeles, 10 University of Utah, 11 Ann and Robert H