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Although subgroup analyses were performed, these are exploratory and may be underpowered, and residual confounding cannot be excluded MRI assessment relied on semi-quantitative MOAKS scoring rather than volumetric BML measurement, which may limit sensitivity to subtle structural changes

Common contributing factors include poor posture, sedentary lifestyle, improper lifting technique, excess body weight, and genetic predisposition

Open fractures that break through the skin carry a significant risk of bacterial contamination, and infected bone heals poorly or not at all

The FDA reaffirmed the decision on December 19, 2024

It also examined markers of cardiac and renal injury to understand AF4s therapeutic potential in hypertension