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Godex markedly reduced fasting blood glucose and insulin resistance indices while enhancing insulin sensitivity in NAFLD mice ( Mechanistic insights into L-carnitine's effects on insulin resistance include: Inhibition of NF-B-mediated chronic inflammation: NF-B signaling promotes systemic inflammation and directly interferes with insulin signaling pathways, exacerbating IR (60)

Applications for polypeptide modifications and in hydrogel-peptide conjugates have been reviewed elsewhere (Hoyle and Bowman, Cyclization and Stapling of Peptides Peptide cyclization is a naturally occurring PTM, with cyclizations occurring between N - and C -termini, between side chains or between the side chain and either the N - or C -terminus of the peptide chain

doi: 10.1158/2159-8290.CD-19-0338 138 LiaoPWangWWangWKryczekILiXBianYet al