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Neuromelanins binding affinity is affected by increased ROS and iron

Mycotoxins enter the body through inhalation, ingestion, or skin absorption, and once inside, they trigger a cascade of inflammation that disrupts neurological, endocrine, and immune functions

When administered orally, up to 23% of individuals experience gastrointestinal problems such as nausea and vomiting, which are the most frequent side effects

This requires overcoming challenges related to inter-individual variability, methodological standardization, establishing causality, and ensuring the stability and generalizability of biomarkers across diverse populations, as emphasized in studies focusing on decoding the complex microbiota metabolome (164)

10.1074/jbc.M116.734533 21 DeNicolaG