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A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

Using the wrong diluent can introduce contaminants or alter the solution's pH, leading to aggregation (clumping) or degradation

Raucci A, Palumbo R, Bianchi ME (2007) HMGB1: a signal of necrosis

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The data in Figure 24 confirm this expectation by demonstrating that D-Nle-Cys-Ile-NH-(CH 2 )5-CONH 2 and D-Nle-Tyr-Ile-NH-(CH 2 ) 5 -CONH 2 , which bind HGF with high affinity (Figure 23) and effectively attenuate HGF-dependent processes (Figures 25, 26, 27 ) completely block HGF dimer formation