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The absence of family histor y is more indicative of an autosomal recessive trait such as LAL-D, particularly if the patient has also tested negative for autosomal dominant genetic causes such as HeFH and FCH

& De Caterina, R

275(3): 1699707 Ohtani Y, Nishiyama S, Matsuda I

Given the burden of cognitive dysfunction, a better understanding of biological underpinnings is crucial, and MRS allows a unique insight into biochemical changes linked to cognitive performance