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This difference is due to absorption of drug from the patch directly into the systemic circulatory system, while orally administered preparations are absorbed into the gastrointestinal and portal circulatory system and exposed to first-pass metabolism before entry into the systemic circulatory system and becoming available in the central nervous system (Figure 2).47 Subsequently, STS results in higher and more sustained steady-state levels of selegiline compared with the oral formulation

PMID 38067631

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