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The main difference between Bimix and Trimix is that Bimix contains two active ingredientspapaverine and phentolaminewhile Trimix has an additional ingredient, alprostadil, which may enhance effectiveness for certain patients

PMID: 11347747

Safety: Its important to note that while AOD-9604 demonstrated excellent safety and tolerability, the clinical development program was ultimately discontinued because efficacy for weight loss did not meet regulatory approval standards

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