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5.3 The prospects and limitations of tumor microbiology therapy Microbial-based therapies, including oncolytic viruses and bacteria, have demonstrated unique potential in cancer treatment due to their ability to specifically target tumors, induce immune responses, and enhance the efficacy of conventional therapies (Zhou et al., 2018

However, the mechanism of action of glutamine in the immune cells of cancer patients remains unclear, and further research is needed on the inhibitors of glutamine metabolism and their mechanisms of action, as well as the potential broader application of combined immune checkpoint inhibitors

10.1016/j.jfda.2017.11.001 [PMC free article: PMC9322224] [PubMed: 29567262] [CrossRef] Iyyaswamy A, Rathinasamy S (2012)

Effects of Sweeteners on the Gut Microbiota: A Review of Experimental Studies and Clinical Trials

Other than IDO, cancer cells can also use TDO, an immunosuppressive enzyme, to avoid immune destruction