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Deacetylation of BMAL1 by SIRT1 resulted in destabilization of the protein and disturbed the circadian rhythm [38]

Kuhn et al., 2016)

A critical mechanistic link between inflammation and depression involves activation of the indoleamine-2,3-dioxygenase (IDO) enzyme, which diverts tryptophan metabolism away from serotonin production toward the kynurenine pathway