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This led to a dose-dependent increase in SELENOP levels in N2a cells [112]

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Status Scheduled requires update after meeting Evidence update log 17 July 2026 Initial evidence review published using regulator, anti-doping, trial-registry and peer-reviewed sources

Some observational research has also suggested a slight increase in lung cancer risk linked to long-term, high-dose B6 and B12 supplementation, particularly among men and smokers, although this kind of study cannot prove that the supplements caused the cancers

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