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In iron overload, labile iron fractions with strong redox activity appear in the blood and cells

As a long-term effect , a connection between a high exposure to air pollution and signs of premature skin ageing had been reported by several researchers

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The latter includes phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) resulting at least in part in an increased mitochondrial metabolism [100] along with the inhibition of the anti-oxidative response by phosphorylating members of the fork head box O transcription factor (FOXO) family [101, 102], of the mitogen-activated kinase (MAPK/ERK) as well as of the hypoxia-inducible factor (HIF) signaling cascades [103105]

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