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Converging data indicate that microbial functionsparticularly the metabolism of short-chain fatty acids, bile acids, gases, and tryptophan-derived productscan influence epithelial barrier integrity, mucosal immune tone, motility, and gutbrain signaling, thereby modulating IBS symptoms

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Sisslerfeld, the largest contiguous development reserve in northwestern Switzerland, is selected as the case study due to its diverse zoning areas and development potential