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Age-related cognitive decline

35 are preclinical, and one is on a human trial, and so it was very limited in human research, so we got a lot of rats and dogs that were utilized for these studies

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However, these studies are still limited to lab only, and cant be directly applied to human use

To bridge the adult behavioral data to the in vitro mechanistic theory, organotypic hippocampal slice cultures that maintain an environment representative of an intact hippocampus were employed and evaluated for treatment-induced spinogenesis