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However, extensive characterization of these mice has shown that the introduction of human APOE variants results in functional APOE and APOE protein levels comparable to wild-type levels (Knouff et al., 1999

For induction of ferroptosis in HT-1080 cells (seeded on 96-well plates at 2,000 cells per well), RSL3 (0.3 M), erastin (2 M), ML210 (1 M), ML162 (1 M), FIN56 (1 M), BSO (500 M) and FINO2 (5 M) were used

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As shown in Table 1 and Figure 6, in the pursuit of structurally diverse NNMT inhibitors, researchers have identified certain macrocyclic peptides that bind to NNMT, displaying potent inhibition with Half-maximal inhibitory concentration (IC 50 ) values as low as 229 nM (Van Haren et al., 2021)

Ranson, Marie