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1995 Dec 15;55(24):6045-52

Cisplatin-resistant NSCLC cells induced by hypoxia transmit resistance to sensitive cells through exosomal PKM2

As NADPH is intrinsically connected to the levels of reduced GSH in cells through the activity of GR, we sought to determine if the GSH/GSSG ratio shifted as well towards a more reduced state in rSCC-61

Evidence Evidence that CFS/ME patients are low in methylation cycle metabolites: B vitamin evidence In a small study of 58 chronic fatigue syndrome patients with a history of Epstein-Barr infection and B-cell immunodeficiency, 81% responded to folinic acid