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Curcumin is the most abundant curcuminoid in turmeric, providing about 75% of the total curcuminoids, while demethoxycurcumin and bisdemethoxycurcumin generally represent 10%-20% and less than 5% of the total curcuminoids, respectively (108)

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As a cofactor of dioxygenases, -KG regulates signal transduction and controls gene expression through epitranscriptomic or epigenetic mechanisms 20

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[2] Research indicates that ALA may improve symptoms of diabetic neuropathy: for example, clinical trials and meta-analyses have shown that intravenous ALA (typically 600 mg per day for 3 weeks) may significantly reduce neuropathic pain, paresthesia, and numbness in diabetic patients