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Prolonged systemic hypoxia has been shown to affect the redox equilibrium and induce oxidative stress [98, 99]

It is not clear, for example, how BBB permeability alterations, mitochondrial damage, or microglial activation led to cognitive impairment in COPD

Altered cholesterol metabolism in Niemann-Pick type C1 mouse brains affects mitochondrial function

doi: 10.1038/srep14630 (2015)

If increased dye uptake variance was due wholly to heterogeneity in exposure to liposomes, no correlation between levels of the two dyes would be expected