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Discovery of methylene thioacetal-incorporated -RgIA analogues as potent and stable antagonists of the human 910 nicotinic acetylcholine receptor for the treatment of neuropathic pain

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Chen et al (140) demonstrated that epigenetically upregulated NOP2/Sun RNA methyltransferase family member 2 (NSUN2) binds to the mRNA of SLC7A11, catalyzes 5-methylcytosine methylation and then recruits the specific recognition protein Y-box-binding protein 1 to form a stable protein-RNA complex, thereby enhancing the stability of SLC7A11 mRNA and promoting the upregulation of SLC7A11 expression at both the mRNA and protein levels

Located in the cell membrane, the insulin receptor exhibits a tetrameric structure with two -chains and two -chains, serving as the primary hub for insulin action and orchestrating the insulin signaling cascade

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