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If SQOR activity declines or its regulation fails, H 2 S shifts from a signaling molecule to a cytotoxin, leading to mitochondrial dysfunction, decreased ATP production, and heightened inflammation

Other antioxidant systems In addition to GPX4, VKH 2 , and CoQH 2, which act as scavengers for free radicals, ferroptosis can also be mitigated by antioxidants such as -tocopherol [44], superoxide dismutase (SOD), and catalase (CAT) through efficient neutralization of ROS

As glutamine levels drop in the TME, T cells and NK cells experience functional impairment, including reduced production of IFN-, thereby diminishing the cytotoxic immune response against the tumor [63]

How to resolve the enigma of diurnal malate remobilisation from the vacuole in plants with crassulacean acid metabolism