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Naley jednak pamita, e wikszo tych bada jest wci we wczesnej fazie, a efekty u ludzi mog si rni od tych obserwowanych w laboratorium

A randomized, double-blind, placebo-controlled trial in 153 older adults taking the antidepressant citalopram found daily supplementation with 500 g vitamin B 12 , 2 mg of folic acid, and 25 mg of vitamin B6 for one year did not reduce the severity of depressive symptoms but increased the response to drug treatment and helped to prevent symptom relapse (112), suggesting B-vitamin supplementation might provide some benefit as an adjunct therapy

For research handling it is typically reconstituted with bacteriostatic water