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Description

Petersson J, Schreiber O, Hansson GC et al (2011) Importance and regulation of the colonic mucus barrier in a mouse model of colitis

When activated by exercise, metabolic stress, or exogenous administration in a research setting, MOTS-c translocates from the mitochondria to the cell nucleus, where it directly regulates the expression of genes related to energy metabolism, oxidative stress resistance, and cellular homeostasis