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Hayward, Matthew M

In addition to activating NRF2 and inducing antioxidant enzymes, some NRF2 activators may also affect other signaling pathways, potentially interfering with related biological processes

Treatment of F344 rats and B6C3F1 and Swiss mice with oxazepam caused hepatocellular centrilobular hypertrophy in both species, but rats did not develop liver tumors, whereas the mice developed hepatocellular neoplasms as well as hepatoblastomas (Bucher et al