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In patients with active axSpA, continuous treatments with NSAIDs instead of on-demand treatment is conditionally recommended, whereas on-demand treatment is strongly recommended over continuous treatment for patients with stable disease There is ample experience 29,30,31,32,33,34,35 that NSAIDs improve axSpA symptoms (defined by pain, stiffness or by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)) compared with placebo 36

The model was first fitted to the training concentrations (37.5 and 25 M doxorubicin), and then used to simulate the test concentrations (50, 12.5 and 10 M doxorubicin) as a means of blind validation, showing good accordance between the experimental and in silico outputs for all concentrations of doxorubicin

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Int Immunopharmacol 125:111207 Kishimoto Y, Yoshida H, Kondo K (2016) Potential anti-atherosclerotic properties of astaxanthin

doi: 10.1038/s42003-021-02060-x 56 YanHZouTTuoQXuSLiHBelaidiAAet al