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A., Oluwadare, T., Ojo, T

February 6, 2021

However, bioavailability through nasal delivery is lower than injection

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The high-dose strategy was associated with a nonsignificant tendency for symptom improvement and greater diuresis, weight loss, and net fluid loss at 72hours but also with a transient worsening of renal function.9 Route of administration In patients with AHF, the current recommendation is to use a stepped and progressive intravenous diuretic therapy based on the diuretic response, starting with high intravenous doses (twice the daily baseline oral dose) and progressively decreasing the dose until the minimal effective oral dose is reached.2 In addition to the oral and intravenous routes, subcutaneous administration is an option