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Knockdown of each gene diminished GSH levels, and knockdown of Idh2 and Me1 also increased GSSG levels, thus elevating the GSSG/GSH ratio (Figure 6D)

Emission maximum in the present assay was observed to occur at a wavelength of approximately 485 nm

iii) The lumen is segmented by applying distance transform on the centerline

in contrast, only Cu chelator treatment show potent rescue effect on such excess Cu 2+ -induced cell death, suggesting that cuproptosis is distinct from other forms of cell death