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5.2.1 Key antioxidant pathways in ferroptosis regulation In critical oxidative stress response pathways, Nrf2/HO-1 signaling is paramount, with Nrf2 serving as a key endogenous antioxidant factor

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Precisely how H4R and the release of these mediators are connectedeither directly or indirectlyas well as the identity of the H4R-bearing cell (discussed further below) remains to be determined

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10.1172/JCI90519 92 Santana-CodinaN.ManciasJ

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