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Hepatocellular senescence induces multiorgan senescence and dysfunction via TGF

Gender and the use of neuroleptics in schizophrenia

Elesclomol is widely recognized to induce copper overdose and cell death (139), by acting as a copper ion carrier with a hydrophilic pore in its centre, to which Cu2+ ions can bind easily, facilitating copper entry into cells, thus increasing the intracellular copper concentration (140), and this, in-turn increases ROS levels, triggering oxidative stress (141) and ultimately cell death

Here, we sought to extend our previous findings by performing untargeted Proton Nuclear Magnetic Resonance ( 1 H-NMR)-based metabolomics and targeted ultraperformance liquid chromatography/mass spectrometry (UPLC/MS) analysis on a well-characterized cohort of PD patients whose serum amino acid profile was already reported 5

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