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10.1038/s42003-025-07738-0 21 LeaM.NourE.HilaD.ZaitY.ScharffY.Ben-YosefS.et al (2022)

In TGR, and more generally in TrxRs, electron transfer from NADPH to the enzyme is fast and practically irreversible and so an actual ES complex (NADPH-TGR) is not significantly populated during the catalytic cycle 17