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In particular, it has been demonstrated in animal models that psychosocial stress results in depression-like behavior through the activation of oxidative and apoptotic mechanisms, including increased ROS levels, lipid peroxidation, reduced Bcl-2 expression, and increased caspase-3 22

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Fan K, Zeng L, Guo J et al (2021) Visualized podocyte-targeting and focused ultrasound responsive glucocorticoid nano-delivery system against immune-associated nephropathy without glucocorticoid side effect