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A simple N -methylation of the primary carboxamide substituent in 1 led to 2 , which retained the TYK2 JH2 affinity (including the sub-micromolar potency in the TYK2-dependent IL23 and interferon (IFN) cellular assays) of 1 and proved to be inactive against the JAK (including TYK2) JH1 domains

FIGURE 1 1.2 COVID-19 pathogenesis Coronavirus is an encapsulated, non-segmented, and positive (+) RNA virus with a single-stranded sense found in animals, such as dogs, camels, bats, and cats

OTUB1 stabilizes mismatch repair protein MSH2 by blocking ubiquitination

J Am Pharm Assoc 46(1):44-52

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