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Description

Most of the pyruvate is converted to lactate, whereas some of it is converted to acetyl-CoA, which, in turn, is used in de novo fatty-acid synthesis (Figure 1)

ABCG1, ATP Binding Cassette Subfamily G Member 1

Haploinsufficiency of PTEN results in a lethal T cell-mediated autoimmune disorder characterized by spontaneous T cell activation and reduced Fas-mediated activation-induced cell death