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Retatrutide is a triple receptor agonist that activates GLP-1, GIP, and glucagon receptorsthree critical hormonal pathways involved in metabolic regulation

Intraneuronal A was detected at 2 months, progressing to intraneuronal lysosomal accumulation of C-terminal fragments (CTFs) and lysosomal abnormalities by 12 months (Gandy et al., 2010