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Nonetheless, it is important to highlight the high heterogeneity and limitations of the studies, such as (1) low to moderate methodological quality, (2) variation in a selected population, (3) a lack of inclusion and evaluation in different skin types, (4) small sample sizes, (5) variable designs, (6) types of chemical peels, (7) deficient efficacy measures, (8) short-term or no follow-up, (9) attrition rate, (10) heterogeneities in the grouped results, and (11) poor conclusions

Furthermore, increased strand breaks generation caused activation of poly(ADP-ribose) polymerase (PARP), a zinc finger DNA-binding protein, known to deplete intracellular NAD + reserves as well as energy stores, thus ultimately resulting in cell death (429)

Fukuda, S

Solution dilution is the single highest-impact modification

PTECs are highly sensitive to hyperglycemia (14)