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The research was partially supported by a grant from the U.S

142 Additionally, H 2 O 2 suppresses mTORC1 activity, reducing phosphorylation of 4EBP1, which then binds eIF4E, preventing interaction with eIF4G, thereby blocking translation initiation

[1] Note: unlike the thiazolium ring of thiamine pyrophosphate, FAD does not act as an electron trap or electron sink, but rather as an electron conduit between the reduced redox-active disulfide and NAD +

Furthermore, prolonged senolytic administration may trigger compensatory mechanisms, resulting in rebound senescent cell accumulation