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International journal of sport nutrition and exercise metabolism, 29 (2), 106-116

10.1007/s12035-009-8071-2 60 JohnsonE

Treating RPE cells with the iron chelator deferoxamine (DFO) can lead to a reduction in intracellular iron ions (154), an increase in genes related to iron transport, a significant elevation in the level of hypoxia-inducible factor HIF2, and impairment of mitochondrial function, indicating that the RPE is the main target tissue for DFO toxicity, resulting in atrophy and degeneration of the RPE and posing a risk of retinal detachment

Sanyal et al

232,233 A single controlled trial in 19 men with idiopathic infertility found hCG, used in conjunction with human menopausal gonadotropin (a combination of LH and FSH), for three months resulted in a higher pregnancy rate than placebo, and positive effects on sperm parameters were found to be correlated with higher inhibin B levels