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Potentially as a consequence of the heterogeneity of functionally redundant cell signaling networks and multiple genetic alterations 43 , glioblastoma remains largely refractory to current approaches of cancer therapy targeting specific signaling pathways 44

J Appl Physiol 63:152157 Huang J, Philbert MA (1995) Distribution of glutathione and glutathione-related enzyme systems in mitochondria and cytosol of cultured cerebellar astrocytes and granule cells

The tricarboxylic acid (TCA) cycle, glycolysis, fatty acid metabolism, and nucleotide synthesis are key metabolic pathways that maintain intracellular homeostasis and regulate DNA repair mechanisms