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Description

Copper is involved in melanin synthesis (hair pigmentation) and is a cofactor for enzymes involved in keratin cross-linking

Pathogenic and non-pathogenic variants are proposed to exist

Thalassemia major patients using iron chelators showed a reduced plasma thioredoxin level and reduced thioredoxin reductase activity, despite elevated oxidative stress

Guyda, H

In addition to DNA synthesis, B12 is vital for energy production, as it acts as a cofactor for certain enzymes involved in cellular energy metabolism in the mitochondria